@brokefoot Thanks for the suggestion. I tried deactivating all texture mods and trying again, but it ended in the same result. I enabled all update notifications and will be keeping a closer watch. If I enable all of my texture mods and get rid of the edits to the Fallout4Custom.ini file, everything loads again and I can play, but with fewer mods (as per the original post). I'll keep watch for possible texture updates.