Actually, I am having the same problem, and I am not running/do not actually have the mod linked in reply; indeed a started a new game with all mods off (the f4se) and I still get the same problem:: "E" and "R" will not open containers or workshops, tho holding "V" still opens workshop, and "E" still picks up free/lose items. I just ran the game without f4se, but with all my mods (150+) and "E" and "R" now work. I have no fix (apologies) but just wanted to confirm that I too am having an issue. ::EDIT:: FYI for those who might need it: deleting *CustomControlMap.txt* from the ...Fallout4/data/F4SE folder seems to fix the issue for me.
