@Stardusk link your specs, might be a problem there. (+ have u got latest drivers ?) Same here until now, lowering shadows to medium still results in crashing. Low works fine for now, but I'm not getting my hopes up until I've got proof.
I'm having same issues aswel and they tend to get very annoying since they occur more and more frequently. I've tried changing sound settings, running with the TESV.exe no succes though. Will try the shadow thing aswell then :), keeping you up to date. win 7 x64 AMD Athlon II x-64 Quad core ~3.0Ghz ASUS M4N68T-M V2 8Gb RAM Nvidia Geforce GTX 460