BartlettBob

I'm having two problems with Skyrim SE. The first happens when I set up a new profile and enable the mods I want to have for that playthrough. Once that's done, I click on the sksee64 loader. The game begins to load and I am at the default intro (this is the second problem. I have "Alternate Start - Live Another Life" enabled but the game disregards my choice). I CTRL-ALT-DEL out of the game and try to reload. As the game begins to load I get an error message to the effect that some mod is missing. I cancel the game and return to Vortex. I click on the "Plugins" choice under the "Mods" column and "oops" all of my mods are disabled. This problem only occurs with Skyrim SE. I also play the legacy version wit no issues.

I have a, hopefully, related problem. No issue with opening screen brightness, instead I'm having what might be described as an infinite load screen. A little background. I use Profiles in Vortex to allow me to have different characters use different sets of mods. This is in both Skyrim and Skyrim SE. So I have created a new Profile and set the "Save Games" to "yes". Then I boot up Skyrim. The game starts, I click "New" at the Main Menu. Screen goes to black with the words "Bethesda Game Studios". That fades and is replaced with "Presents". The black background begins to fade being replaced with "Skyrim" and the opening sequence where two wagons ,carrying prisoners, and traveling along a road begins to appear. Everything in second wagon seems to be OK, people talking, facial expressions showing, bodies moving; but the horses don't appear to be walking and the background scenery doesn't change. It's as if the wagons are on a treadmill. They never get to Helgen and the game doesn't start. Ralof and the horse thief have their dialogue then nothing. Screen doesn't go dark but there is no further movement from then on until I C-A-D and close the game. Anyone have any idea what's happening? Note: The game works fine in existing profiles. I can create new characters in them and everything loads as it should. Also, when I tested this, I made sure that only the essential mods, FNIS, USSEP, SKSE, etc. were enabled.