Hi. I've had this problem before and it remained totally unanswered. Skyrim instantly CTDs. Works fine vanilla, but it may be due to my ENB for some reason. I have enbdev no 221, the antifreeze 9 patch, did everything Realvision said to do and I also have SKSE but Skyrim crashes instantly. My computer is amazing, I've never had any lag issues before. The Papyrus log says this [08/27/2014 - 11:27:02PM] Papyrus log opened (PC) [08/27/2014 - 11:27:02PM] error: Native function GetUseSound in empty state does not match existing signature on linked type Potion. Function will not be bound.[08/27/2014 - 11:27:02PM] Update budget: 1.200000ms (Extra tasklet budget: 1.200000ms, Load screen budget: 500.000000ms)[08/27/2014 - 11:27:02PM] Memory page: 128 (min) 512 (max) 76800 (max total)Also, LOOT's report viewer is empty except for a red line at the top. Plus, the BOSS log doesn't say anything is out of the ordinary. Windows 7. Game is located in the normal programfiles(x86)/steam/steamapps/common/skyrimNewest game version, all DLCs. Latest version of NMM. Using LOOT, TES5EDIT, BOSS, latest version of SKSE, ENBdev. On top of this, here's my load order GameMode=Skyrim Skyrim.esm=1Update.esm=1Dawnguard.esm=1HearthFires.esm=1Dragonborn.esm=1morrowind_skooma.esp=1waterbreathing breathless emerge.esp=1undergroundlake.esp=1killarrows.esp=1actorball.esp=1arrowtotheknee1.esp=1darthmaulwarpaint.esp=1divinepunishmentforarrowstotheknee.esp=1godpush.esp=1max.esp=1mysticmanor.esp=0posion.esp=1skullwarpaint.esp=1unlimitedartifactenchanments.esp=0unlimitedenchantments.esp=0unrelenting grip.esp=1waterwalking.esp=1crimes against nature.esp=1dbnightingale.esp=1esisbattlepack.esp=1esiscitypack.esp=1esisenviropack.esp=1masterthetimeandspacetoggle.esp=1morrowind_mm_theme.esp=1lanterns of skyrim - bridges x2 - onoff_bright.esp=1lanterns of skyrim - villages.esp=1magicka sabers crystal.esp=1magicka sabers expanded.esp=1magicka sabers.esp=1moreargoniantints.esp=1sceniccarriages.esp=1 Finally, here are two screenshots of my Skyrim folder. http://puu.sh/bbMoF/bfbbb141f9.pnghttp://puu.sh/bbMmc/15e7657a77.pngThe two screenshots capture the whole folder, by the way. There's nothing in-between.If anyone could help me, it would be incredibly much obliged. Thanks.