No, Vortex doesn't use any python, except for the build system. It uses javascript (electron/node.js) though, which is also available on Linux. As you pointed out: other tools may not be native on those platforms, they have to be run through wine either way. But who cares? The games supported by those tools are windows-only as well, if you run skyrim through wine you can run skse through wine. A native version is always better, then you don't have to worry about a Wine layer getting it right. Could you release a Wine bottle of the app? Sure, but it'd be bigger for what is a fairly small app, and again native tools are ideal. If some tools aren't cross-platform then alternative code would need to be sought to replace them. How much work would that entail or how much work would it take to move the remaining apps to Linux vs. a Wine bottle? Not sure, but either way, a cross-platform app managing native apps as well as non-native ones would be superior to a non-native app managing native and non-native apps.