ChemBoy1

What version of Windows and Vortex are you using? Have you tried running the .NET installer from Microsoft website, outside of Vortex?
https://dotnet.microsoft.com/en-us/download/dotnet/6.0

You probably have a network connection issue between Vortex and the GitHub repositories. This is often caused by a VPN, firewall, antivirus, or your ISP.

This is a memory access violation crash from the game. it is probably caused by one of your SKSE plugins. You have quite a few loading there, and the error message does not cite a specific module or script, unfortunately.
 
This has nothing to do with Vortex. You can ask on the Skyrim SE forum.
https://forums.nexusmods.com/forum/8877-skyrim-se/

That is a very old message that means they are not adding new extensions to that repo. They are added to the site now. You can make PRs to fix bugs in existing extensions. I already have and was specifically invited to do so by the current main Vortex developer, Nagev. 
Some of the extensions are built from TypeScript. If that were the case (it's not for this one), Nagev may need to make the changes himself rather than directly merging your PR. 

Are you using an external drive? It says your file system does not support hardlinks nor symlinks. This is usually because of exFAT file system. You must use only NTFS drives with Vortex. 

Just drag and drop the zip into the Mods tab. You might need to use the arrow in the bottom right corner to expand the dropbox.
 

You can change the theme, and even install new themes from the site...
https://www.nexusmods.com/games/site/mods?categoryName=Themes
This one might work well for you, depending on your flavor of colorblindness: https://www.nexusmods.com/site/mods/867
You also have full control over color selection in the Theme settings. 
Anyone in the community can make a theme for Vortex. If you don't see one you need, you are more than welcome to create a more colorblind-friendly theme. Or ask someone to do it for you.

Yeah, it is not recommended to use Vortex with external drives. That is the reason the writes are so slow. It has to do with how Windows handle IO for external drives. 
And yes, you are copying the FULL data for each and every file, rather than just writing links. That will take a VERY long time.
You need to at minimum format your external drives as NTFS to have any hope of decent performance. That will allow you to use Hardlinks Deployment. Links are a feature of the NTFS file system.  exFAT does not have links support.

This is patched in Vortex 1.14, currently in beta. Games can no longer block profile switching after the update. 

This issue has already been reported to the devs. Only way to fix it is for them to update the extension. 
https://github.com/Nexus-Mods/game-oblivionremastered/issues/5

It appears the Oblivion Remastered extension is missing a folder write check. Just create the folder shown in the error message, then restart Vortex and it will work. 

You would have to move data back and forth from the Vortex Roaming AppData folder. You could use a 3rd-party folder sync application to keep these folders the same across the 2 machines, but that could carry some risk of data loss or state corruption. 
You could use collections or some of the other available Vortex extensions to export/import your mod list back and forth between the PCs. This would be much safer. But you would have to manually manage the load order syncing and other settings.

It's a FOLDER selection dialogue. You will not see individual files, only folders. 
And yes, if the executable name changed, the extension needs to be updated for the new name. 
 
Edit: It is indeed different GTA5_Enhanced.exe
 
My next big project is making a new version of the RDR2 extension. I can work on one for GTA5 Enhanced as well. The existing extensions don't work to install a lot of new modding patterns anyway.

A couple things:
1. The Slime Rancher extension does not have native support for the Xbox version.
2. When manually selecting the installation folder (auto discovery won't work), you need to go into the "Content" folder and select that.
3. Because of how Xbox store DRM works, renaming the exe file may cause problems for you. 
Best thing to do would be to ask the extension author to add Xbox version support. 
https://www.nexusmods.com/site/mods/256?tab=files

Are you using the new version of the extension? The one made by infarctus. There was an old version that is no longer supported. You can get the new one by removing your existing extension, restarting Vortex, and then adding the game again to download the current extension. Your mods will be preserved. You will need to reinstall your full mod list to get them all installed properly. 

You need to "stop managing" the game in Vortex. You were probably still managing the game when you uninstalled it. It's only supposed to show the notification once, so not sure why you are getting it again. 
Or use the little gear icon to suppress if it's there. 

What game are you using? The message will provide more detail on the reason deployment isn't possible. 

Possible? Yes, definitely. Someone would just need to take the time and effort to create the extensions. 

I am not sure I understand what you are asking for. It is up to each individual Vortex game extension to locate whether the game is installed or not. If the extension is not bundled with Vortex, it cannot search for the game until you have downloaded and installed the extension.

So, if what you're asking for is a view in Vortex that shows which compatible games you have installed, this is not really feasible since it would only be able to show you games installed that ALSO have the extension installed. 
All supported games can be found in the Vortex Games tab.

The extension does not have support for the Epic version of the game. The executable name is probably different for the EGS version. This is not uncommon. The extension author would need to add support for multiple executable names to the Vortex extension. 
https://www.nexusmods.com/site/mods/301?tab=posts

This error means Vortex is not able to communicate with GitHub to update the bundled extensions for Vortex, which would include Skyrim VR (though it has not been updated recently). 
Could you provide a screenshot of the error? 

You are trying to mod the Xbox Game Pass version of the game. The extension for Coral Island does not support that game version currently. Contact the extension author to request Xbox game version support.
You'll notice that the extension wants "Win64" for the binaries folder and the executable name where you have "WinGDK"

Vortex is not magic. It cannot suddenly support new games unless someone writes a JavaScript extension for the game. This takes a significant amount of time, energy, and knowledge of the Vortex API. 
Vortex supports far more games than any other mod manager (~430). I have created about 25% (almost 100 games) of the game support myself. 
If there is a specific game you want support for, you can politely contact myself or one of the other active extension developers in the community and make a request. 
Or, learn how to create it yourself: https://github.com/Nexus-Mods/vortex-api/issues/31

Make sure you are using latest Vortex 1.13.7. If not, update. You may need to download the new installer from the site if your version is too old to auto-update.  Check your Vortex Settings that the option to "Allow Symlinks without elevation" is enabled. If that doesn't fix it, check your UAC settings in Windows. This is a part of the Control Panel. You can find it by searching in the Start Menu for "User Accont Control Settings". It should be set like the image below (this is the default setting). 
 

You just confirm to download it again, then proceed with the install.....