I would love to see a completely revamped alchemy system, a series of new apparatus which can be exchanged from inventory to benches as acquired. These would modify not only the properties of potions, but my hope would be that certain effects are not available unless the right apparatus is present. This would also allow the PC to carry a mortar and pestle with them to make the simplest and weakest of potions out of a few ingredients if necessary. It would also cross over into hunting/survival/necessities/crafting/economy/balance eventually. A big realism mod.