Hmm, i was running skyrim 4gb and skyUI with SKSE no problem until now i installed SD (for more hotkeys) and the 4gb version doesn't detect SD and when i run the original exe SD works aswell as skyUI but i get a warning messege on the top right saying skyUI could not detect the required version of the SKSE. My skyrim and SKSE are up to date and i'm guessing so is SD. If someone could offer me a solution i would be greatful. I can't play with 8 hotkeys and there is no way i'm going back to the old UI. EDIT: SKSE and SD run fine when i use the SKSE loader, but i still can't get the skyrim 4gb to run SD. Ah well, i'll look around more.
