Same problem here, except my game will randomly refuse to load savegames giving me CTD even though it was fine when I was making them. If memory patch is disabled, game works pretty solid. Well, at least I can load my savegames without CTD. Something was definetly changed at memory allocation for this game. When this patch was introduced, there was different setting in SKSE.ini (GiveFirstBornToSheson=1) and SKSE memory log plugin was showing that only the first block is used. Now I can see that both block are used at the same time no matter what size they have. And even if the first block size is more than enough, the second block is still used. I'm not stating that this patch doesn't work for everyone, but it definetly doesn't work for some people including myself and even more, it makes things much worse, causing random CTD. Because using old SKSE doesn't change this behavior, I can only presume that memory allocation was changed in the game itself to remedy CTD, but instead Bethesda made things even worse. All I can say for certain is that anything above 256 in one block cause random CTD for me.