A couple of things stand out; You are using Dynavision, oHud, and Project Nevada, all of which affect UI. Are you also using the Unified Hud Project? If not, DO SO. CASM.esp can cause short term slow downs and instabilities if you never manually save. Try saving manually every 30 minutes or so. Also, if you haven't already, update to CASM with MCM. I accidentally picked up the non-MCM one a few months back and it caused problems. MergePatch looks kinda sketchy. Is it from the Nexus site? Or did you make it yourself? Custom patching can be weird unless done PERFECTLY. Try disabling that and see what happens. If all else fails, try opening your load order in FNVEdit and see if it throws any errors at you. Let me know if any of that works. EDIT: Oh, and back up your saves before trying any of this. Multiple load order changes can be wonky on a game.
