Yes, I do that all the time. I once went into a way to high level crypt, I was about level 20-25 and even the normal dudes two-shoted me, if they wasn't using a two-handed weapon because then I was dead. There were two bosses, one Deathlord with a bow and one without. The one with a bow was impossible, so after 4 deaths I just sneaked past him instead. The other one took three 30x damage dual power sneak attacks to kill, but at last he was dead. First I sneaked his body guards, then him casting Pacify between every sneak. The tricky part was that he was sitting in a throne, so I couldnt sneak him while he was there, so I had to lure him with my bow, cast Pacify and sneak him on his way back.