Thanks for helping but I did find something. I removed the SKSE files from my Skyrim folder and my bow now works. Going to slowly reinstall the mods and see which one triggers it. Guessing with my luck it won't happen again :) Edit: I removed all Mods totally, deleted files from directory and added them back in 1 at a time similar to original install. So far so good. I have my SKSE and SkyUI mods working and my bow back to normal. Thanks for talking me through this, the only thing I can think of if there's something in those UI mods that modifies the mouse buttons at all?