I've wanted a similar thing where the feral neighbours can be captured and tamed with the beta wave emitter (or some mentats and island fog remedy, same function as what the Ghoul in the TV show has), and the frozen neighbours can be resuscitated with some combination of Curie's medical knowledge and the mysterious serum. Just because.
Or. You collect samples from the frozen/feral neighbours and make synths of them.
Neither scenario is realistic or completely accurate to the games logic, but I prefer it to undoing their previously established vanilla stories.
The ferals could provide security like Junkyard Dogs and the pre-war residents could provide happiness.