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Are you using Sneak Tools?

I had the same problem, but after poking around for some time I figured it out. And there is a way how to fix broken npcs/items and you don't need to turn off block activation permanently or reinstall the mod. However the bug may appear again sometimes, but when you know how to fix it it is not really that bad. I made a short video about how to fix it.

Ayporos - Nope, not that one. My first guess was Animations mod, but more I think about it more suspicious I am towards some UI mod. I have to continue trying.

Georgiegril - So I edited all dirty edits (except where they were made on purpose, like Convenient Horses), I made sure my unrecognized mods are properly placed, but SkyFalls and few others does not require any particular place. Nothing helped. And after reading Ayporos's edit I tried to remove SSME but it did not help neither. I use Skyrim Startup Memory Editor-50305-1-8-0-0, Skse_1_06_16 and my Skyrim version is 1.9.32.0.8 And I did not removed any mods. I was just collecting mods I liked and when I felt I am ready to play I started new game. But I still can't understand why the containers stopped suddenly working. I even tried to remove mods related to the items stored inside affected containers (Acquisitive Soul Gems). But I think more and more containers will become stuck. Here is the log. Mods with Bash Tag were already "Wrye Bash-ed". And the only inactive mods are which Wrye Bash disabled.

Georgiegril - Ok, I will try everything you recommended and I will see what will happen, thanks. ;) Ayporos - Yes, I have all updates and patches. I used many STEP recommendations and Zemalf's blog for advices. And it is really odd, I know. If the containers would not work since the beginning I would understand something is wrong, but my problem is weird. The same with the gold. Same item, same ID, but some are pickupable, some not...

Dear Nexus community members, I have a problem with picking up items and opening certain containers. For example in the end of Pinewood dungeon there is a pile of ores, gold and some emeralds etc. I was able to take everything except few Septims, some ore and one ruby. My crosshair showed the items but activating it didn't do anything. But much bigger problem is with "stuck" containers. I was storing soulgems in wardrobe and suddenly I was not able to interact with it. I just heard click noise and the containers didn't open. This happened after few hours of gameplay. And now the same thing happened to wardrobe where I have my food. 30 hours later. I have a decent amount of mods installed so I tried deactivating animation related mods but it did not help. Player.tia didn't fix this neither. So, any ideas? I use Breezehome Fully Upgradable and I have my mods sorted using BOSS. And one more thing, probably not related to this. Once I entered Drunken Huntsman but I appeared in Breezehome. And once I lockpicked cage door but I was teleported to the beginning of the same dungeon. Thanks for replies.