*EDIT* To anyone else reading this post that has this same problem and is seeking a solution, I wish I could help but I can't, sorry. I honestly have no idea what made it work again. Hopefully something here helps you (Purr4me's suggestion would be a great place to start). Good luck. So I built a new computer a few weeks back (which I am typing this from now, see specs below), and installed fallout 3 and all my mods (same configuration as my old computer). It worked great up until I kept getting bluescreens and OS corruption a few days ago (which -seems- fixed by now, all has been stable). What seems to have remedied the aformentioned issues was updating my drivers, graphics, chipset, usb, sound, etc. and I also installed almost every windows update there was (including the service pack). But now, as a result, Fallout 3 will NOT open no matter what I try: -every compatibility mode -run as administrator -disabling all mods but F3 and DLC ESMs -toggling archiveinvalidation off and back on -toggling GFWL disable off and back on -I already have the busethreaded ai and so on -using fallout3.exe, fose_loader, Fallout_fullscreen, and Falloutlauncher -Directx end-user runtime web installer -install Microsoft Visual Studio 2005 C++ Redistributable -and more that I can't remember lol I do not think this is a mod issue, because like I said before, the same thing happens if I disable ALL mods. If I watch the processes tab in Task Manager I can see that fallout3.exe shows up for just a second before disappearing. Does anyone have any ideas on how to salvage this? I really really don't want to reinstall because it's such a pain in the ass... any help is appreciated thank you. Windows 7 professional 64 bit AMD A10-7850k (Kaveri) 8gb Gskill ripjaws 2400 RAM ASrock Fatal1ty A88x Killer mobo 1TB WD blue HDD 600W EVGA PSU (using Kaveri's APU as video card which is actually pretty impressive on its own)