I'm playing detective on my superhumungous setup: Erased all the mods, only put back the biggies (so, thirty framework-type mods and "Alternate life" so this doesn't become an eternity in Oblivion). Read the faq about hdt, used "xpmse/bbp" new game teleport to the luxury suite, Slept in the biggie bed. Woke up Crash with hdt PE, OK without it. This needs repeating a few hundred times using different skeletons, etc. I have not found the cause, only the symptoms: It's (probably) related to the skeleton and the physics extension