Man, I feel your pain. All I have been told lately is to get a new pc :( I myself have the same issue after 1.10 and I have tried EVERYTHING... updated drivers, reverted to old drivers, removal of all mods, .ini files, interface files, saved games, deleted f4, reinstalled f4, removed f4se, I even reformatted & tried a pirated version of 1.9.4. Everything I do leads to a ctd on startup, and beth wont help me because of my specs. Something about 1.10 fried my pc, it was working so well before and now for some reason i simply cannot understand. good luck I hope your able to figure it out. I currently am playing newvegas again, and practicing in the geck for it. sadly, im just going to have to save up and buy a new computer.