Sorry for the late reply, I understand your plight, as I know what it feels like too ): I'm not so sure about the 'best' way for optimization, but there's lots of guides out there, take a look at this maybe: http://en.uesp.net/wiki/Oblivion:Technical_Support But I have a few questions: Which version of OR are you using? I see the "OblivionReloadedArenaCombat.esp", but afaik, I don't remember installing that last time I downloaded OR. It's also insisted in All Natural's readme to use Enhanced Vegetation instead of Natural Vegetation. And which type of 'saves do you use? I've heard overwritten, quick, and even auto saves increase crashes and whatnot. I suggest trying any of the mods listed below too if you don't haven't atm: Oblivion Stutter Remover MoreHeap EngineBugFixes 4gb Ram Patcher CTD and Memory patch ENBoost (incompatible with ENB) NVAC - New Vegas Anti Crash (yes, this really works with oblivion, check the desc) Clean up Fast Exit