There's like 3 different issues mixed in this old thread: Setting the max memory allocation to an incorrect number: backup+delete the skyrim.ini SKSE getting corrupted: reinstall SKSE. Then that bInvalidateOlderFiles being set to 0: use ModOrganizer and as a bonus it sets that right for you automatically in its initweaks file.Only problem is using ModOrganizer means your skyrim.ini is in a different place, deleting it in the normal place wouldn't work, it's one more variable when you have a fubar skse install, and it may be hard for some to use it because you have to start everything from within it. There's no perfect solution. But overall it's just don't mess with things unless you have to, and understand the tools provided to you. And if you're going to start clean, make sure you really do: INI files, external utilities such as SKSE, and a new save for testing. Actually, you might as well do that kind of stuff *before* trying to reinstall Skyrim.