Hah! I found the problem :happy: Twas a modified version of "UF3P\WhiskeyBottle02full.nif" (the "full" scotch bottle model provided by UF3P) that I'd recently made that was causing Uptown such violent fits for some unimaginable reason. But without "Unofficial Fallout 3 Patch.esm" in the load order, see, the game would use the default scotch bottle model, and so Uptown wouldn't crash. My Radish.esp, having overriden the UF3P version of Scotch to tweak its weight, also had "UF3P\WhiskeyBottle02full.nif" set as the model to use, and so would make Uptown crash. The modified model file in question worked fine everywhere else in the game, though, and even works in Uptown now that I just opened it in Nifskope and re-saved it with Auto-Sanitize on. Weird. :huh: