Alright, I've been thinkering with the GECK lately and I think I've found the *best* way to prevent NPCs from picking up items. Here how it goes: - No A.I. Acquire never seems to work on items as my NPCs keep picking them. - Ignored by Sanbox can't work alone as the item needs to be checked as a persistent reference. Otherwise NPCs will still pick up items. Therefore, the best way to prevent NPCs from picking up items would be to check both Persistent Reference and Ignored by Sandbox, so this way the NPC will ignore the item in question. You won't even need to create a RefID to do so. Might sound like a lot of work, but NPCs will no longer pillage food display and such. That's all.