I have played the game for quite a period of time with hundreds of mods (over 300 esp plugins; don't know how it's possible). A while ago, I finally updated to 2.0.16 and installed a few more mods. The save now insists that I am missing one major mod, but it keeps changing its mind about which one it is. First it was Ordinator. I checked and found that it was enabled and that everything was in order, but reinstalled it anyway and ran LOOT. Now, it is Imperious that is the problem. Starting a new game confirmed that it was indeed not there, and reinstalls changed nothing. I recently tried running LOOT again, and this time my efforts only succeeded in changing the missing mod to Palaces and Castles Enhanced. It's just a symptom of something worse, I think. When I actually open a save - even ones from a new game - everything goes berserk. Notifications from various mods fire randomly, and the spell Frostbite shoots out of my character's face. I don't recall exactly which mods I added, but I remember being sure that none of them were the problem. Going over the plugin limit is possibly the cause, but then why was I able to get away with it for so long? EDIT: Reinstalling SSE didn't work, either.