Are you using the memory patch? If not, you can read about it at www.nexusmods.com/skyrim/mods/50244/? Have you cleaned your dlc with TESVEdit? Gopher's guide: www.youtube.com/watch?v=fw3g_N1jcZQ Have you uninstalled any mods with an esp midway through gameplay? For me that was cause lots of CTDs and I prefer to start a new game to avoid that. I see you're using Requiem, and it looks like 1.9.3 if you have the bugsmasher esp. You've probably looked in these places, but be sure to check out Requiem Patch Central for 1.9.3 http://www.nexusmods.com/skyrim/mods/61621/? If it's something to do with your other mods or load order, maybe someone else can help.