I strangely have the same issue, I can eat, drink, etc. But when it comes to "using" Skoma or Potions. The sound effect is made but the potions are never consumed or go into effect. Super weird.
I feel the culprit maybe animated potions/poison I played around with that mod a lot. Enabling it and disabling it. If I find a solution will post it here.
I wish I could use "Spell Hotbars" for potions, etc. would be an awesome cure.
I also can't use favorited potions, so no luck there.