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You can do that for testing purposes, but don't play on with a save game after that point. If you disable a mod, everything it added to the game will be lost once you saved your game without that mod. This may also break quests from mods, reset companions and leave leftover scripts in your savegame, that can cause further issues. If something doesn't work the way it should in a modded game, you should always try to find the cause of that issue. How to go about this: Do what WastelandAssassin suggested: Start with a new character, get to Riften and the TG quests as soon as posiible. Now systematically disable mods (10 at a time or so), until you're able to start "loud and clear". Now re-enable the mods you disabled last again one by one, until the problem occurs again. This way you can find the "culprit". You can then try to make a "clean save" without that one single mod. Google how to make a "clean save" if you need to - there are a lot of tutorials / guides on this. Sounds as a reasonable suggestion. So, I start a new game with all mods activated and and after I got to Riften, attempt to complete the quest, disabling the most possible mods, until I get a result, is that correct? After I find the culprit, disable if it is a simple mod and do a clean save. Disabling the mods in a new game won't have any undesirable effects on my main character saved games, right?

Thanks for the info. But I do not intend to remove the mods altogether, since I am pretty satisfied with how the game is modded. The things is the bugged quest - TG 02 ( Loud and Clear ), which is unable to start, due to reasons beyond me. Brynjolf simply refuses to introduce me to Mercer, which bug the whole quest chain. I attempted to start TG 03 ( which starts, but prevent me from doing the side jobs for Delvin and Vex and makes Tonilla irresponsive ). As far as I have understood from many various Internet sources, the thing responsible for the bug is a mod ( which is always different, as it seems, since I don't have neither of the mods, causing the problem, save for Undeath ) So I guess I only want do disable my mods temporarily, determine which one is responsible and turn them back on. Is it possible this operation to be carried out safely?

Hey, folks! Basically, I have a persistent bug with a vanilla quest, which as far as I have read on various Internet topics is caused by some mods ( different for different people ). I am very very far into the game, my acc is around lvl. 72 and I have do desire to begin again. So, I guess my question is how to safely disable the mods without braking the game and/or quests? Of course, I have various hard saves from the beginning of the game up to this moment and I guess I can disable the mods, load an early save and use trial and error there. Would that have any effect on my most recent save? So, what should I do? I do apologize, if my questions sound noobish, but I have experience with mods only from the perspective of a standard user, who have no idea about any indebt info about modding. Thanks in advance!

Yeah, I am using Loot from the very beginning. It sorted the mods to begin with, but there was the occasional bug every now and then. Primarily there were bugs with some NPC's behavior, but right now the most notable bug is the quest with the Thieves Guild. I am really NMM user and prefer the manager to handle most if not all of the work. Now, if I have a quest already started by some mod and I disable the mod, wouldn't that bug the game even if I enable it later?

Well...perhaps not noob in gaming, but noob for sure in managing mods in games like Skyrim. I got myself knee deep in several bugs, but find my way around most, except for one. Some might have experienced it as well - the quest TG 02 ( Loud and Clear ) for the Thieves guild refuses to start after the completion of Taking care of business. After speaking with Brinjolf he starts to wander randomly at the Ragged flagon usually ending up in ridiculous places, refusing to open the infamous wardrobe and walk to the Cistern. After an hour of research, it was quite obvious the reason is some mod. I tried the usual way of using console commands through some bugged quests and managed to enter the Cistern, spawn Brinjolf to me and add myself as a member of the Guild. Brinjolf was unimpressed and simply walked to one of the side rooms, Mercer paid me no attention and the thieves there acted in a friendly if not very conversational manner. Then I started Dampening spirits via the console, but that made Tonnilia irresponsive. The quest TG 02 does not start even through the console. Up to this moment I am starting to run out of options. I am not certain which mod is causing problems, but I read somewhere it might be Undeath. Most of the mods I use are tested in a previous playthrough, where no such problem occurred. The most obvious way would be to disable my mods and complete the quest and here comes my noobness. I am uncertain how to do that safely. I use around 230 mods, and even in that very moment my acc is filled with modded equipment, which removal will probably lead me to a nice trip to an error message on the desktop. Would appreciate any advice and thanks in advance!