Thanks for looking at it. It is definitely an issue, but I'll try to give more info. Running Vortex 1.9.10
I run the Skyrim Script Extender 64, which I just updated to 2.2.5 from Silverlock.org
When I load a saved game, I get a pop-up with a list of installed dll's for the game that are not enabled in the Creations menu. It's, essentially, my mod list, including things like SKSE64 and bunches of Vortex mods. I also can't screen grab from the game - it doesn't take the Steam shortcut for screen captures anymore, either.
I think the new update plays with Plugins.txt - overwrites it with what's in the creations bin, but I don't have anything from there.
I do wonder if shifting to Skyrim LE and modding it will bypass this mess.
Thanks again,
Brian