There is a really bad glitch that I discovered upon entering Moss Mother Cavern, with a mod Interesting NPCs SE turned on only, the fps drops to 0, usually one frame per few seconds, water appear all around and indication that you are swimming. I could not believe that his mod caused it but it did. Disabled all other mods and left this one, that is how I found out. Disabling Interesting NPCs SE makes all run smooth and without no problems, other mods were turned on as well. I just felt like I needed to tell it, would help someone else if encounter such problem.