I personally would like to see it in chicago. They could do a lot with the area, such as maybe the enclave are the good guys in this or at least the main story would have something to do with the enclave. Within the fallouts they have mentioned chicago being an enclave station and with Maybe dlc or the size of the map you could head on over to Wisconsin, in the deep woods there could be tribes and Yao gui maybe you could even see lake michigan, or Atleast the remnents of it. There is a lot to be done in his region maybe even have the brotherhood be the enemies of the people. I hope, like in new Vegas, you can choose a side that dramatically effects the games ending. I can only hope there is a new fallout :)
