This same issue happened to me this morning, with Avast! being a regular c***. Was able to successfully re-download the SKSE launcher, install, and add the skse_launcher.exe to the exclusions list, but now my game is corrupted! I launch the game (in both SKSE and regular mode), I see the Bethesda Game Studios animation, then the application crashes to my desktop. Anybody having this happen to them? I am going to try to re-install the whole game and see if I can get this issue solved.