Does everyone happen to be using War of The Common Wealth mod? I love the mod personally, but It started giving me issues. I was playing fine (other than being unable to touch my electrical systems in Sanctuary) but randomly I tried to load a save where I happened to be at Bunker Hill and it would ctd before loading. I disabled all mods and it loaded fine. Major pita since I have around 195 mods running, but I weeded out War of The Common Wealth. With it disabled I was able to load into my save where I was at Bunker Hill. A few days later I enabled WOTC since I was away from Bunker Hill and the game played fine for a few days. Then randomly I started getting the ctd when trying to teleport into Sanctuary. I tried running from Abernathy and It would ctd when getting close to Sanctuary. Remembering Bunker Hill I disabled WOTC and I was able to get back to Sanctuary with zero issues. Just for giggles I tried adding a new generator....success. So I went back to all of the old generators, switches, and lights that would ctd me earlier and everything is all cleared up..... I have read also that sometimes Sanctuary can start ctd depending on quest order or completion. In between my initial ctd and now seemingly stable gameplay I did complete a few quests however they did not involve Mankind Redefined as noted above. As a side note, I tried the portal mod trick as explained above and it did not help my situation. Really hopes this helps someone. tldr: Try disabling the "War of The Common Wealth" mod or possibly other mods that change npc spawns or spawn points.