as an experienced modder, i never used this because for my maingame (skyrim AE) it does not make any sense at all. (at least not that i know about..)
if you use merged files in vortex and you use for example zedit (on skyrim se) to merge that files and than archive them and insert them into vortex than SOMETIMES vortex leave the one or other of the merged mods PLUGINS active and than it can happen that you have 2 of the same npc in game, the one you merged and the one from the active plugin ESP inside your game or doubled items that get double loaded but take no farther harm. after merging in vortex you should ALWAYS check the mods that you merged manually and check if they are disabled (they always should be and only the merged esp should be active). if they are disabled, they are causing no harm at all because they not get touched by your game no more and you can ignore them. just write down somewhere what you merged where or look it up to get not confused on future modding sessions.
ghosting would make it unable for these plugins to work but since they are disabled, they wont do their job anyways because your merged mod will do that job now. some people delete that unused ESP's or put them aside in an collection folder...i never did that work, i simply let them disabled and they never caused me any harm. hope that was helpful. have a good one!
I'M ONLY TALKING ABOUT SKYRIM SE (i have no other modding experience than san andreas and skyrim se)
