Thanks for the reply! Feels like I waited forever for a reply lol Unfortunately, I was already doing all of that, to the best of my knowledge. I used BOSS and even double checked to make sure my load order was correct. Everything loaded after SkyRe was clean; in fact, the ONLY files not cleaned were the Bethesda masters, which I am reluctant to touch. After having issues the first time and restoring to vanilla from backups, I didn't use the ReProccer because I didn't use ANY weapon or armor mods. I still had random CTD with no rhyme or reason. I'm at a complete loss. I am fairly new at this, but I've been EXTREMELY cautious, and can't for the life of me figure out what's causing the CTD. Idk if it's relevant, but the CTD doesn't start until I get to whiterun. The first time it happens in a new game is upon entering Dragonsreach, but after that it's completely random. It doesn't CTD every time I enter Dragonsreach, just the first. And after that, it happens all the time. Entering a menu, entering a different building, even just out running around in the woods. I'm so infatuated with SkyRe that I don't really want to play without it, but I'm reluctant to install anything until I have this sorted out. I'm still sitting here with a clean vanilla install, and I've uninstalled absolutely everything else. NMM, BOSS, TES5Edit, etc. I want to start from scratch this time. Any more thoughts?