I have completely installed all of the DLC, and several mods. Including immersive weapons and armor, SkyUI, and the High Res Texture pack. As far as I can see the UI looks exactly the same and the textures look exactly the same. And after several hours of gameplay I have not come across any different armor or weapons. I thought the mod manager was supposed to work well. I also have Fallout 3 and it at least recognizes the mods. It recognizes the mods I have on it by crashing the second I start the game up. I know it is recognizing the mods because when I just have the vanilla game running it works fine.