Not sure if this Fix is for everyone but it seems to be a re-occurring issue with Bethesda's games. The random CTD is more than likely being caused by something called "ffdshow" which will be in the all programs section of your start menu. From there you will want to open up both the ffdshow audio decoder and the ffdshow video decoder, they'll both look the exact same once they are open aside from what they are. Go into the DirectShow control section (Again on both of them) check off the "Don't use ffdshow in" checkbox and add the exe file for skyrim in the given line ( It should look like this SkyrimLauncher.exe;TESV.exe;), I also added the launcher exe for skyrim just because I like being cautious. Then hit apply and close the windows, Skyrim should now run without the completely random CTD's anymore. At the very least mine doesn't anymore, though don't give items to people if you have them equiped yourself because that causes ctd's apparently. Doing that has fixed the random, no error ctd issues I had when playing Oblivion, Fallout 3, and Fallout: New Vegas.