I've been having a slow escalation of problems for a week or so now until the game would refuse to load at all starting yesterday. I've tried multiple different angles (uninstalling, reinstalling, removing all mods, checking them one by one, etc.) and it seems to be something going on with NVSE as the game is loading to full-screen play mode. For a while now I've been having errors where when I'd load the game through FOMM clicking the NVSE button, the Steam box would pop up, and then the New Vegas loading screen where you click Play to actually load the game, and the sound wouldn't play and it'd crash out. Just canceling out of the error and trying again would work. Then yesterday, it suddenly got much more severe where I could only get it to correctly load once every 10 to 15 tries. If I disable NVSE, the game loads fine from FOMM or the regular launcher. I've discovered if I go through the process from FOMM with NVSE enabled and click Play as quickly as possible when the New Vegas loading box comes up, just as the error box is popping up, the game will still load and the NVSE check with the console ingame still comes back as '1', even when I alt-tab out to cancel out of the error box. So is it something going on only in the launch of the game process? EDIT: Well, so much for the speed click workaround, that doesn't work anymore either. The game does still load sometimes, but I have to launch from FOMM a good 10-15 times per try to finally get the music to play when the New Vegas login box loads up.