I just had the same issue as well, leaving the Chantry in Lothering. Also, an MSI motherboard. However, I found a post from 2010 with the same issue, and the person lowered the graphic settings before they did the transition back to Lothering and it worked. It worked for me as well. Once I was clear of Lothering, I put my graphic settings back up to Very High on Graphics and High on Textures.