I truly know the woes of 2560x gaming. I just remodded my entire Skyrim, as I was stuck below 32-ish fps, sometimes looking at a slide-show. (I have a 2560x1440 screen, an MSI GTX970 Gaming 4GB video card (oc'd a bit), an i5-4690K (@4,3 GHz) and 8GB of RAM (the next 8 gigs are arriving tomorrow).) You should give http://www.nexusmods.com/skyrim/mods/6491/? a try, to pinpoint your bottleneck. Sadly my bottleneck was my GPU running at 99% on the "idle skyrim" and just couldn't cope with a fire-magic fight in front of Whiterun. And not so surprisingly that the SSD only ever effects the load time, but without enb I'm easily at my limit of 60 FPS. As I couldn't possibly give up on ENB I chose to downscale my graphics: 1K textures for everything, and 2K for hair, armour, weaponry, skin: what I'll constantly see up close. I'm almost done with my play-through's mod-build, and during testing my lowest FPS ever was around 24 (highest outdoor around 42ish, indoors at 60). That's all I can help with right now.