fwiw, after upgrading to the new F4SE, iâd get the loading screen and the ENB version info and then CTD. I could lainch the game with F4SE with no mods. My fix was to deactivate a F4SE dependent mod, reinstall it and then activate it. DEF_UI was a bit tricky (make sure you have the latest translation file), but otherwise, this method worked on all of my F4SE dependent mods, updated ot not. Hope this helps someone :)