If you're into manual installation and don't any NMM or any mod manager, Here's an option: -You can copy your whole skyrim folder and files into another location, kinda like backup. (If you have adequate hard drive space.) - delete any unwanted mods in original location. (Make sure don't delete any essential mods and any Skyrim files.) -next, you can install your different set of mods into original location. - verify your new mods on skyrim launcher data file. -run the game via SKSE if you're still using any SKSE dependent mods.