i have same issue, starting skse loader from MO 2 crashes at startup but if lauching from root folder game starts. Game version 1.5.53 - SKSE 2.0.10 " There was an update to the SSE exe today. That means that skse64 will not work. Just to be clear. The version check in skse64 is there for a reason. Basically, anytime they change the exe version the address's that skse64 hooks into change. If the version check were not there any save made after the exe update would be corrupt. Period. "