Played all last year without this problem. Did a fresh update of ENB and all my mods (about 120) staring from a vanilla profile (using Mod Organizer). First load went without a hitch. Subsequent loads - CTD more than half the time. This year I'm trying Skyrim Realistic Texture Overhaul, which may be increasing the amount of data to load on startup. What seems to work ATM is hitting shift+F12 to disable the ENB at the menu, load the save, then re-enable the ENB. The CTDs only occur on loading saves. Once in the game, I run mostly very smoothly (see below) without crashes. I've found that occasionally, especially after using showracemenu, I'll go from a usual 59fps down to about 10-15. Only thing that seems to fix that is save, exit to desktop and reload. I'm still trying to figure that one out. I may try disabling ENB before doing the racemenu thing and see if it helps. EDIT: Went into my Users\...\AppData\Local\Skyrim folder - even though I didn't think I had any duplicate listings in the loadorder or plugins.txt files. Surprise!! The only plugins listed were for the base game and DLCs that were dated last May when I first installed the game on this rig. Copied the files from my ModOrganizer profile into this folder and have had no trouble loading saved games. Yes! Regarding the drop to 10 fps - unloading ENB prior to showracemenu seems to fix it, while not doing so results in a severe framedrop. Still testing that.