I am having the same problem, I don't have any save game bloating, I am using a number of the same mods as you but none that I have recently installed, being this problem only showed up recently, I have another side effect though usually sound will stop working (music will still be running) and npcs/textures won't load, then after a few seconds my game will freeze, right now I only suspect something wrong with d3d9 (because I switch from enb/realistic to rcrn and the problem persisted), or a loose script will let you know if I figure anything out