Interesting NPCs and Inconsequential NPCs are an absolute must. And try INIGO, too. Consider trying Duke Patrick's Archery And Heavy / Light Weapons Combat, instead of SkyRe. Completely changes the way you play the game, in a fun, challenging, and realistic way. To summarize the dozens of features that this mod offers, duels against some enemies can last for up to 10 minutes in some cases. In short, this totally removes the "hit LMB until he dies". This mod is fundamentally different from vanilla Skyrim, in my opinion even more than SkyRe and Requiem together.