Game version 1.2.37, SKSE 0.1.3. It crashed as well originally when I first tried the day one patch with the original release of the script extender, so I don't think the version is the reason. As for no steam path, I install franchise games, and/or, heavily modded games to program files. Just a way I organize things. Would reinstalling into the default steamapps folder be the issue somehow? Though it wouldn't make sense how a different folder on the same drive would cause injecting problems. Never caused an issue with previous Bethesda games. If you start game by running Fallout4.exe - is it started immediately or Launcher menu opens? Try to rename Fallout4Launcher.exe to Fallout4Launcher_original.exe , then f4se_loader.exe to Fallout4Launcher.exe and then start game from steam.