I have the Nvidia GTX 1060 6gb, an i5 3330 and 8gb RAM, I play on Ultra at fullscreen and it run fluently... My game is strongly modded (and I have all DLCs), but I took care about everything fits together :/ Maybe it could have something to do with the Nuka World DLC, because it only crashes when I come closer to the point where the Nuka World transit station should have to be... I play kind of role play characters, so the last time I went this far to the west is many mod installations ago, so the crashes could be caused by many mods :/ Do you think that it could help to uninstall every mod, try to get to the transit station again and then reinstall one by one again?