Fallout 4 NG Update Crashing Unless AI toggled Off

[jwarner]

So I've got a weird issue going on here. After running through troubleshooting steps with the new update for Fallout 4 I kept getting constant CTDs when in combat. It's not F4SE related, I've refreshed my ini files, I've reinstalled a few times, and it still happens on new and old saves.

What I discovered is that it only happens in combat with humanoid NPCs. Animals and bots have no issues. If I disable combat AI through the console, then I don't get crashes against said NPCs. Even more interesting is that I disabled combat AI on one of these tests and one of the NPCs was still in combat with a turret nearby. The game didn't crash at all during this. Yet, when I re-enabled combat AI and the NPC attacked me, a few seconds later the game crashed.

 

Anyone encounter something like this before and have any idea what's going on? I've never installed any AI mods, but would that possibly fix this?