Question on Modding LE - does each part need to be modded separately?

[Ophiucus68]

I'm just now installing LE for my PC and taking a look at modding. I ran a cross a reference to installing an LE mod "for each game".

Now, I've modded Fallout NV and 4 extensively so I was expecting to drag and drop into the ME mod manager and activate mods just once but will I have to somehow do it for 1,2, and 3?

And while on that, will mods made specifically for Mass Effect 3 work for LE?