Exhaustive problem prevention

[SteadyNeuros]

So I'll be undertaking my first heavily modded playthrough of Skyrim AE/SE, involving about 600 mods rather than the dozen or so I've used in the past. As I've been configuring my modlist, I've been surprised by how long it took me just to make it through the intro sequence uncorrupted.

I'm aware that it depends largely on which mods are in use, but generally speaking, I wanna know what the likeliest in-game trouble spots and crash sites are. Moreover, I wanna know an efficient methodology for testing those problematic areas and junctures, because I'm really trying to pre-empt CTDs without starting my playthrough in earnest -- after all, is there anything more immersion-breaking?

If someone could shed some light on these points, I'd be very grateful.