"Activate" Button Stops Working After 5 Minutes of Gameplay

[TheDocGore]

I found an interesting little problem recently that essentially sprouted randomly while playing the game. I found that if I play the game for about 5 minutes, my activate button (no matter what I have the button set to) will stop working (eg. I can't open doors, open containers, talk to people, basically anything that requires hitting the activate button.) I had my activate button set to "E" and after that stopped working, I assumed it was a problem with the button "E" (even though the "E" button works perfectly fine in the console), so I switched my activate button the "R". After using that for even less than 5 minutes, it stopped working as well. At that point, I couldn't use "E" OR "R" as an activate button. I researched this online and saw a similar issue being related to codecs so I installed the K-Lite Full Codec but that has not solved my issue. At this point, I think a mod might be causing the issue, but I am unable to tell for sure.

 

Active Mod Files:

00  Oblivion.esm
01  IDKRRR_C_race_closed_mouth_version.esm
02  Unofficial Oblivion Patch.esp  [Version 3.5.2]
03  UOP Vampire Aging & Face Fix.esp  [Version 1.0.0]
04  Oblivion Citadel Door Fix.esp
05  DLCShiveringIsles.esp
06  Unofficial Shivering Isles Patch.esp  [Version 1.5.6]
07  Natural_Weather_HDR_by_Max_Tael.esp
08  Natural_Weather_HDR_by_Max_Tael_RD.esp
09  Natural_Habitat_by_Max_Tael.esp
0A  Idle Dialogue.esp  [Version 1.3]
0B  RAEVWD Cities.esp  [Version 1.9]
0C  RAEVWD New Sheoth.esp  [Version 1.7]
0D  RAEVWD Imperial City.esp  [Version 1.9]
0E  FormID Finder4.esp
0F  Streamline 3.1.esp
10  DLCHorseArmor.esp
11  DLCHorseArmor - Unofficial Patch.esp  [Version 1.0.8]
12  DLCOrrery.esp
13  DLCOrrery - Unofficial Patch.esp  [Version 1.0.6]
14  DLCVileLair.esp
15  DLCVileLair - Unofficial Patch.esp  [Version 1.0.10]
16  DLCMehrunesRazor.esp
17  DLCMehrunesRazor - Unofficial Patch.esp  [Version 1.0.7]
18  DLCSpellTomes.esp
19  DLCSpellTomes - Unofficial Patch.esp  [Version 1.0.1]
1A  CapesandCloaks.esp
1B  DMACArmor.esp
1C  Immersive Weapons.esp
1D  DLCThievesDen.esp
1E  DLCThievesDen - Unofficial Patch.esp  [Version 1.0.13]
1F  DLCThievesDen - Unofficial Patch - SSSB.esp  [Version 1.0.13]
20  DLCBattlehornCastle.esp
21  DLCBattlehornCastle - Unofficial Patch.esp  [Version 1.0.10]
22  DLCFrostcrag.esp
23  DLCFrostcrag - Unofficial Patch.esp  [Version 1.0.9]
24  Knights.esp
25  Knights - Unofficial Patch.esp  [Version 1.1.6]
26  Grass Overhaul.esp
27  Natural_Vegetation_by_Max_Tael.esp
28  RealisticForceMedium.esp
29  RefScope.esp  [Version 2.1.2]
2A  FasterArrows250.esp
2B  Enhanced Grabbing.esp  [Version 0.5]
2C  IDKRRR_C_race.esp
2D  IDKRRR_C_race_closed_mouth_version.esp
2E  1em_Vilja.esp  [Version 4.04]
2F  Companion Neeshka.esp
30  Oblivion_Character_Overhaul.esp  [Version 2.0]
31  1310-Chamelion-NoRefraction-TESSource.esp
32  LandMagicPatch.esp
33  OblivionReloaded.esp
34  NoIncreaseWalkSpeed.esp

Any help would be appreciated.

EDIT: I should also point out that saving the game, and immediately loading the game fixes the issue temporarily.